Can cause ulceration of the mouth and GI disturbances (e.g. stomatitis and diarrhoea)
bone marrow depression
hepatotoxicity
renal failure
skin reactions
alopecia
ocular irritation
arachnoiditis in intrathecal use
megaloblastic anaemia
osteoporosis
precipitation of diabetes
arthralgias
necrosis of soft tissue and bone
anaphylaxis
impaired fertility.